Fig. 5.
Luciferase reporter on chr1 93,277,007 T > A of JAK2. (a) Fisher's exact test on-site allele frequency in the JAK2 region of each comparison, with chr1 93,277,007 T > A (red dot) is beyond the significance level of 0.001 (−log P > 9.88) in all comparisons. (b) Sequence logo of the Sox5-binding site on JAK2 provided by JASPAR (https://jaspar.genereg.net/matrix/MA0087.1/). (c) Luciferase reporter was applied to H9C2 cells, and JAK2 expression in wild type (T) was significantly higher (t-test P = 2.94 × 10−2) than that in mutation type (A). (d) Luciferase reporter was applied to A673 cells, and JAK2 expression in wild type (T) was significantly higher (t-test P = 4.86 × 10−3) than that in mutation type (A).