Figure 8.

PBN activity is correlated with arousal states. A, Representative traces depicting spontaneous firing rates (red) of PBN neurons and normalized pupil area (blue). B, These metrics were positively correlated. C, Averaged (and 95 CI) traces of firing rate of PBN neurons (red) and pupil area (blue) in response to noxious heat applied to the snout. D, The lag-shifted correlation values suggest that firing rate and pupil area changes are positively correlated (n = 17 cells, 7 animals). E, The positive lag value after cross-correlation suggests that changes in firing rate preceded changes in pupil area (n = 17 cells, 7 animals).