Table 3. Table of Pharmacokinetic Parameters of the QUE Cocrystal Compiled from Data Presented in Table 2 and from the Literature for the Ease of Visualization.
 |
 |
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|---|---|---|---|---|
| cocrystals | AUC (ng·min/mL–1) | Cmax ng/mL | FREL | relative Cmax |
| QUE9 | 7.5 | 285 | ||
| QUECAF9 | 19.2 | 656 | 2.6 | 2.3 |
| QUECAF.MeOH9 | 30.1 | 2612 | 4.0 | 9.2 |
| QUEINM9 | 40.9 | 1401 | 5.5 | 4.9 |
| QUETBR.H2O9 | 74.4 | 840 | 10.0 | 3.0 |
| QUE38 | 467.3 | 911.7 | ||
| QUENIC38 | 728.4 | 5997.2 | 1.6 | 6.6 |
| QUEPIC38 | 817.6 | 7832.0 | 1.8 | 8.6 |
| QUE25 | 3880 | 540 | ||
| QUENIC25 | 15,200 | 710 | 3.91 | 1.31 |
| QUE39 | 0.66 | 580 | ||
| QUEPZA39 | 17.07 | 8730 | 25.86 | 15.05 |
| QUEa | 26.8 | 18.7 | ||
| QUEPTFa | 1705 | 616.8 | 63.6 | 32.9 |
| QUEPROa | 262.8 | 193.1 | 9.8 | 10.3 |
| QUEBET·MeOHa | 743 | 897.4 | 27.7 | 48 |
| QUETHPa | 184.4 | 516.7 | 6.9 | 27.6 |
a
Data obtained in this study.