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. 2023 Jul 21;29(27):4289–4316. doi: 10.3748/wjg.v29.i27.4289

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Stomach illustrative presentation. A and E: Before procedure; B and F: After perforation before therapy; C and D: Course after given therapy into the perforated defect, saline; G and H: BPC 157. Control rats: (1) Before procedure (normal rats, A); (2) after perforation before therapy application (B); (3) after saline application (1 mL/rat into the perforated defect in the stomach) (C and D), immediately thereafter (C); and (4) later (at 5 min following medication, D). BPC 157 rats: (1) Stomach before perforation (normal rats, E); (2) after perforation, but before BPC 157 therapy application (F), and (3) specifically after BPC 157 application (10 µg or 10 ng/kg, 1 mL/rat into the perforated defect in the stomach, G and H), immediately thereafter (G), and later (at 5 min following medication, H).