Table 4.
Application of the 1 mL/rat through the perforated defect in the injured stomach at 5 min following perforation |
ECG changes in rats at 15 min and 60 min following stomach perforation
|
|
15 min
|
60 min
|
|
PQ interval, msec mean ± SD | ||
Control | 64 ± 5 | 67 ± 6 |
BPC 157 10 μg/kg | 50 ± 5a | 50 ± 5a |
BPC 157 10 ng/kg | 50 ± 5a | 50 ± 5a |
QTc interval, msec, mean ± SD | ||
Control | 312 ± 10 | 347 ± 10 |
BPC 157 10 μg/kg | 180 ± 10a | 188 ± 10a |
BPC 157 10 ng/kg | 185 ± 10a | 183 ± 10a |
Heart frequency, beats/min, mean ± SD | ||
Control | 530 ± 30 | 550 ± 30 |
BPC 157 10 μg/kg | 375 ± 10 a | 360 ± 10a |
BPC 157 10 ng/kg | 385 ± 10 a | 365 ± 10a |
P < 0.05, at least vs control.
ECG changes, PQ interval, QTc interval, msec, heart frequency, beats/min, in rats at 15 min and 60 min following stomach perforation. Saline (5 mL/kg, control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min thereafter.