Table 3. Comparison of the Elaborated DES-LLME-LC-MS/MS Method of Tigecycline Determination with the Procedures from the Literature.

method	limit of detection (LOD)	limit of quantification (LOQ)
LC-MS/MS 33 (μg mL–1)	3 × 10–3	1.1 × 10–2
UHPLC-MS/MS 35 (mg L–1)	8.7 × 10–2 to 3.0 × 10–1	0.3–1.0
HPLC-MS/MS 36 (μg kg–1)	0.07	0.19
DES-LLME-LC-MS/MS (μg mL–1) (mg L–1)	1.0 × 10–5 to 2.3 × 10–3	3.2 × 10-5 to 7.0 × 10–3
(μg kg–1)	0.01–2.28	0.03–6.84

method	intraday precision	interday precision
UHPLC-MS/MS35 (%)	5–21	11–22
chemiluminescence immunoassy 8 (%)	8.6–9.8	7.6–12.7
DES-LLME-LC-MS/MS (%)	1.4–7.8	5.4–11.7

method	linearity
LC-MS/MS34 (ng g–1)	50 −10000
colorimetry5 (mol L–1)	2 × 10–8 to 6 × 10–6
DES-LLME-LC-MS/MS (ng g-1)	0.06–40000
(mol L-1)	1 × 10–10 to 7 × 10–5