Table 3. Comparison of Physicochemical and Metabolic Properties of Sonidegib and a Cuneane Analogue^a.

	sonidegib	19
MW	485.51	497.52
logP	4.26 (ref (32))	4.74 ± 0.23
aqueous solubility (mM)	<1.6 × 10–3 (ref 8b)	–
human liver microsome stability	20/70 (ref 8b)	76/19
Clint (μL/min/mg)/t1/2 (min)
mouse liver microsome stability	26/53 (ref 8b)	61/23
Clint (μL/min/mg)/t1/2 (min)

^aSee the Supporting Information for experimental details.

^bThe solubility was too low to be measured.