Table 2. Substrate Scope for the Enantioselective C–H Amidation To Afford γ-Lactams Catalyzed by [Cp*Ir(Boc-AQ-biot)Cl] 10 · Sav Variants^a.

^aConditions: [dioxazolone] = 15 mM, [[Cp*Ir(Boc-AQ-biot)Cl] 10] = 7.5 μM, [Sav FBS] = 15 μM, 200 μL of TFE, 300 μL of MES buffer (0.1 M, pH 5.5), 10 °C, 48 h under air.

^bBond dissociation energy (BDE) computed with the BDE estimator at https://bde.ml.nrel.gov.

^cTON and ee were determined by chiral GC.

^dTON and ee was determined by SFC.

^eTotal turnover number for both cis- and trans-16, cis-/trans-16 = 86:14.

^f[[Cp*Ir(Boc-AQ-biot)Cl] 10] = 75 μM, [Sav FBS] = 150 μM were used.

^g[Cp*Ir(Meoc-AQ-biot)Cl] 9 · Sav S112V was used.