Table 1.
Baseline patient characteristics, overall and by ASPECTS determinations
| Characteristic | Patients, No. (%) | |||
|---|---|---|---|---|
| Overall (N = 343) | ASPECTS0–5 (n = 50) | ASPECTS 6–10 (n = 293) | P value | |
| Age, y | 63.6 ± 12.6 | 61.1 ± 11.0 | 64.1 ± 12.8 | 0.058 |
| Female | 104(30.3) | 9(18) | 95(32.4) | 0.044a |
| Hypertension | 198(57.7) | 30(60) | 168(57.3) | 0.725 |
| Diabetes mellitus | 90(26.2) | 11(22) | 79(27) | 0.410 |
| Hyperlipidemia | 104(30.3) | 20(40) | 84(28.7) | 0.107 |
| Atrial fibrillation/flutter | 133(38.3) | 20(40) | 113(38.6) | 0.848 |
| Coronary artery disease | 67(19.5) | 8(16) | 59(20.1) | 0.495 |
| Current/prior tobacco use | 162(47.2) | 27(54) | 135(46.1) | 0.300 |
| Current/prior alcohol intake | 167(48.7) | 26(52) | 141(48.1) | 0.612 |
| TOAST classification | 0.678 | |||
| Large artery atherosclerosis | 256(74.6) | 36(72) | 220(75.1) | |
| Cardioembolism | 79(23) | 12(24) | 67(22.9) | |
| Other determined etiology | 8(2.3) | 2(4) | 6(2) | |
| Prestroke | 77(22.4) | 11(22) | 66(22.5) | 0.934 |
| Baseline NIHSS | 15.2 ± 4.5 | 18.1 ± 5.1 | 14.6 ± 4.3 | < 0.001a |
| HMCAS | 211(61.5) | 39(78) | 172(58) | 0.010a |
| Signs of early infarction | 215(62.7) | 45(90) | 170(58) | < 0.001a |
| DBP on admission, mmHg | 82.8 ± 15.1 | 82.4 ± 14.6 | 82.9 ± 15.2 | 0.999 |
| SBP on admission, mmHg | 140.5 ± 25.1 | 135.1 ± 27.2 | 141.4 ± 24.5 | 0.052 |
| HbA1c, mmol/L | 6.3(5.7–8.0) | 6.7(5.7–8.0) | 6.3(5.7–8.0) | 0.354 |
| D-dimer, mmol/L | 1.3(0.7–3.1) | 1.7(0.9–3.8) | 1.3(0.7–2.9) | 0.192 |
| Occlusive location | 0.378 | |||
| ICA | 91(26.5) | 17(34) | 74(25.3) | |
| MCA M1 | 150(43.7) | 21(42) | 129(44) | |
| MCA M2 | 22(6.4) | 1(2) | 21(7.2) | |
| ICA + MCA | 80(23.3) | 11(22) | 69(23.5) | |
| IV tPA | 82(23.9) | 7(14) | 75(25.6) | 0.760 |
| Oneset to puncture, min | 412.0(233.5–609.0) | 422.5(280.7–545.5) | 410.0(227.0–615.0) | 0.918 |
| Device passes | 1.5(1–2) | 1.5(1–2) | 1.5(1–2) | 0.255 |
| Balloon-guided catheter | 80(23.3) | 10(20) | 70(23.9) | 0.548 |
| Angioplasty and stenting | 26(7.6) | 4(8) | 22(7.5) | 0.903 |
Significant values in bold
Data expressed as n (%) or mean ± standard devation values
aASPECTS Alberta Stroke Program Early CT Score, TOAST Trial of Org 10172 in Acute Stroke Treatment, NIHSS National Institutes of Health Stroke Scale, HMCAS hyperdense middle cerebral artery sign, DBP diastolic blood pressure, SBP systolic blood pressure, HbA1c glycosylated hemoglobin, ICA internal carotid artery, MCA middle cerebral artery, IV tPA intravenous tissue plasminogen activator