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. 2023 Aug 3;16:91. doi: 10.1186/s13045-023-01480-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Diverse TP53 configurations and disease subtypes impact prognosis. A patients with single hit (left panel) vs. double hits (middle panel) TP53 lesions and the type of configuration for each hit class and various constellations among different myeloid neoplasms (right panel). B Kaplan–Meier survival estimates of patients with TP53 wild type, single hits, and double hits, all patients (left panel) and cases with missense (middle panel) and truncated mutations (right panel). C Kaplan–Meier survival estimates of patients with TP53 single hits and double hits distributed according to different disease subtypes: AML (left panel), MDS (middle panel), and MDS/MPN (right panel). D Kaplan–Meier survival estimates of patients with TP53 wild type and single hit distributed according to different disease subtypes: AML (left panel), MDS (middle panel), and MDS/MPN (right panel). E Kaplan–Meier survival estimates of TP53 double hits (left panel) and single hit (right panel) in acute myeloid leukemia (AML) vs. myelodysplastic syndrome (MDS) in correlation with variant allelic frequency (VAF) for each subtype