Table 2.
Cardiovascular variables and temperature at baseline, after lavage injury and after stabilization of either ARDSNet or maximal compliance (PEEPCmax)
| Baseline | Injury | ARDSNet low-stretch | PEEPCmax | P value (injury vs. baseline) | P value (PEEPCmax vs. ARDSNet low-stretch) | |
|---|---|---|---|---|---|---|
| HR, beats/min | 98 ± 10 | 111 ± 20 | 105 ± 10 | 98 ± 7 | 0.246 | 0.298 |
| BP, mmHg | 87 ± 6 | 95 ± 9 | 89 ± 10 | 92 ± 10 | 0.219 | 0.251 |
| MPAP, mmHg | 18 ± 2 | 22 ± 1* | 28 ± 5 | 26 ± 5 | 0.028 | 0.379 |
| PCWP, mmHg | 9 ± 7 | 7 ± 2 | 13 ± 5 | 15 ± 6 | 0.527 | 0.261 |
| CO, L/min | 3.2 ± 0.6 | 3.9 ± 1.0* | 3.6 ± 0.5 | 3.1 ± 0.3# | 0.027 | 0.011 |
| Temperature, F | 102.7 ± 1.6 | 101.3 ± 2.0* | 101.4 ± 2.8 | 101.4 ± 2.6 | 0.048 | 0.745 |
Variables are expressed as mean ± SD
ARDS acute respiratory distress syndrome, PEEP positive end-expiratory pressure, PEEPCmax maximal compliance PEEP, HR heart rate, BP blood pressure, MPAP mean pulmonary arterial pressure, PCWP pulmonary capillary wedge pressure, CO cardiac output
*P < 0.05 injury versus baseline; #P < 0.05 PEEPCmax versus ARDSNet