TABLE 4.
Multiple Regression Analysis Comparing OCS Use Among Adherent Versus Nonadherent to Controller Therapy (N = 32,172)a,b
| Unstandardized Coefficient, B | Statistic, T | P Valuec | |
|---|---|---|---|
| Adherence to Controller Therapyd | |||
| Adherence (PDC ≥ 50%) | -0.11125 | -4.83 | < 0.0001 |
| Covariates | |||
| Treatmentd | |||
| LTRA | -0.03236 | -1.48 | 0.1391 |
| ICS/LABA fixed dose dual therapy | 0.10715 | 4.10 | < 0.0001 |
| ICS + LTRA concurrent dual therapy | 0.09109 | 2.85 | 0.0044 |
| ICS/LABA fixed dose + LTRA | 0.26946 | 9.02 | < 0.0001 |
| Age groupd | |||
| 5-11 | 0.17173 | 5.42 | < 0.0001 |
| 12-18 | -0.20480 | -6.16 | < 0.0001 |
| 19-40 | -0.04747 | -1.14 | 0.2553 |
| Female | -0.02771 | -1.68 | 0.0923 |
| Race/ethnicityd | |||
| African American | -0.03255 | -1.29 | 0.1976 |
| Hispanic | 0.10294 | 4.71 | < 0.0001 |
| Othere | -0.13610 | -3.56 | 0.0004 |
| Total number of nonstudy medications | 0.05288 | 19.80 | < 0.0001 |
a F = 7212, adjusted R2 = 0.0282, P < 0.0001.
b Adherent = PDC ≥ 50%; nonadherent = PDC <50%.
c Significant at P < 0.05.
d Reference categories: nonadherence (PDC < 50%), ICS, 41-63 years, Caucasian.
e American Indian, Asian, unknown.
ICS = inhaled corticosteroids; LABA = long-acting beta2-agonists; LTRA = leukotriene receptor agonists; OCS = oral corticosteroids; PDC = proportion of days covered.