FIG. 7.

Proposed model for DV entry into human MO/Mφ. The LPS receptor on the cell surface of human MO/Mφ is a heterodimeric complex containing a GPI-anchored CD14 and an unidentified transmembrane coreceptor, pRt. (A) In the absence of LPS, DV utilizes the pRt for infection. (B) In the presence of LPS, occupancy of the pRt by LPS blocks the access for DV entry. (C) Blockage of CD14 with anti-CD14 MAbs precludes the LPS from occupying the pRt and makes it accessible for DV. pRt, putative transmembrane receptor.