Table 1.

Reported IC50s of Regorafenib and Sorafenib to Raf1 pathway proteins {Wilhelm, 2004 #2778;Wilhelm, 2011 #2779}.

Raf family protein	IC50 – Regorafenib	IC50 – Sorafenib
Raf1	2.5 nM	6 nM
B-Raf	28 nM	22 nM
B-Raf (V600E)	19 nM	38 nM
PDGFRB	22 nM	57 nM