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[Preprint]. 2023 Jul 27:2023.07.25.550489. [Version 1] doi: 10.1101/2023.07.25.550489

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Figure 5. — Branaplam and risdiplam treatments reduced repeat expansion in RPE1-AAVS1-CAG115 cells. Average repeat gain of non-induced RPE1-AAVS1-CAG115 cells with treatment of either branaplam (a) or risdiplam (b), with the color indicating the drug concentration. Each treatment group and timepoint had five cultures analyzed, except risdiplam day 0 which had three. (c) Drug cytotoxicity quantified by high-throughput image analysis of cells treated with DNA labeling of dead cells. (d) Average background autofluorescence pixel intensity. For c and d, 81 images were analyzed per treatment.