Table 2.
Genetic variants significantly associated with incident CVD in people with T2D in basic model.
| CHR | POS (rsID) | Effect Allele | Ancestry | Frequency | HR (95% CI) | P | Het P | Sample Size |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| 1 | 181855562 (rs147138607) | G>C | European/European American | 0.018 | 1.20 (1.00–1.44) | 0.047 | 0.756 | 24,457 |
| African American | 0.127 | 1.22 (1.12–1.33) | 2.3×10−6 | 0.381 | 8,929 | |||
| Hispanic/Latinx | 0.065 | 1.26 (1.03–1.55) | 0.027 | 0.198 | 3,163 | |||
| East Asian | 0.050 | 1.55 (1.07–2.25) | 0.021 | 0.469 | 2,511 | |||
| Combined | 0.107 | 1.23 (1.15–1.32) | 3.6×10−9 | 0.713 | 39,060 | |||
|
| ||||||||
| 4 | 11444867 (rs77142250) | T>C | African American | 0.013 | 1.89 (1.52–2.35) | 9.9×10−9 | 0.363 | 9,748 |
|
| ||||||||
| 6 | 155665441 (rs335407) | C>T | European/European American | 0.027 | 1.33 (1.19–1.50) | 1.4×10−3 | 0.664 | 29,910 |
| African American | 0.084 | 1.18 (1.05–1.31) | 3.8×10−3 | 0.891 | 7,765 | |||
| Hispanic/Latinx | 0.033 | 1.34 (0.99–1.81) | 0.055 | 0.596 | 3,163 | |||
| East Asian | 0.026 | 0.92 (0.45–1.88) | 0.810 | 0.541 | 2,511 | |||
| Combined | 0.055 | 1.25 (1.16–1.35) | 1.5×10−8 | 0.859 | 43,349 | |||
Three distinct genetic loci increased risk of incident CVD among individuals with T2D with genome-wide significance in time-to-event analysis (P<5.0×10−8). CHR, chromosome; CI, confidence interval; Het P, significance of heterogeneity; HR, hazard ratio; POS, position in GRCh37/hg19; rsID, reference SNP id.