Figure 2. Loss of APOE ε4 is associated with absent amyloid pathology and reduced tau pathology in a 90+ year-old control.

Subject 1 is a neuropathological outlier among age-matched ε3/ε4 individuals in their (a) CERAD staging of amyloid plaque density; (b) Thal staging of amyloid plaque regional distribution; (c) Cerebral amyloid angiopathy staging; and (d) Braak staging of neurofibrillary tangles (tau pathology).