Table 1:
Demographics of ADSP cohorts
| Cohort | Dx | N | Sex |
Age |
APOE
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Female (%) | Median age [IQR] | 22 N (%) |
23 N (%) |
33 N (%) |
34 N (%) |
44 N (%) |
24 N (%) |
|||
|
| ||||||||||
| ADSP WES | AD | 8723 | 61.8% | 75 [70–82] | 29(0.3%) | 540(6.2%) | 3884(44.5%) | 3462(39.7%) | 568(6.5%) | 237(2.7%) |
| CN | 9617 | 63.4% | 84[76–89] | 83(0.9%) | 1530(15.9%) | 5762(59.9%) | 1864(19.4%) | 133(1.4%) | 244(2.5%) | |
| Other | 2163 | 51.4% | 75[69–82] | 17(1.0%) | 209(11.8%) | 984(55.7%) | 455(25.8%) | 60(3.4%) | 41(2.3%) | |
| Total | 20503 | 61.5% | 79[72–87] | 129(0.6%) | 2279(11.3%) | 10630(52.9%) | 5781(28.8%) | 761(3.8%) | 522(2.6%) | |
|
| ||||||||||
| ADSP | AD | 12133 | 60.4% | 72[64–80] | 27(0.2%) | 558(4.6%) | 5003(41.2%) | 4943(40.7%) | 1327(10.9%) | 270(2.2%) |
| WGS | CN | 16988 | 63.7% | 73[66–81] | 78(0.5%) | 1605(9.4%) | 10735(63.2%) | 3900(23.0%) | 357(2.1%) | 311(1.8%) |
| Other | 7240 | 55.8% | 75[69–81] | 33(0.5%) | 645(8.9%) | 4111(57.0%) | 1953(27.1%) | 316(4.4%) | 151(2.1%) | |
| Total | 36361 | 61.0% | 73 [65–80] | 138(0.38%) | 2808(7.7%) | 19849(54.6%) | 10796(29.7%) | 2000(5.5%) | 732(2.0%) | |
Abbreviations: Whole-exome sequencing (WES), Whole-genome sequencing (WGS), Diagnosis (Dx), Alzheimer’s Disease (AD), Control (CN)