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[Preprint]. 2023 Jul 26:2023.07.22.23292754. [Version 1] doi: 10.1101/2023.07.22.23292754

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Differentially expressed genes in ASXL1 CHIP mutation carriers (n=3) versus age and sex matched non-mutation controls (n=27) were enriched in black module in STARNET macrophage RNAseq data. Left upper panel: Volcano plot of differentially expressed genes (DEGs) between ASXL1 CHIP mutation carriers versus age and sex matched non-mutation controls in STARNET CAD cases. Differentially expressed genes were highlighted in pink. Top upregulated and downregulated genes with the smallest p-values or with the biggest log2 fold changes were labeled with gene names. Differentially expressed genes that overlap with black module genes were highlighted in black. Left bottom panel: Top 10 enriched gene ontology (GO) terms for differentially expressed genes in ASXL1 CHIP mutation carriers versus non-mutation controls. Bonferroni corrected p<0.05 was considered statistically significant. Right upper panel: Visualization of black module inferred from STARNET macrophage RNAseq data. Top key drivers were highlighted in pink. Right bottom panel: Dot plot for the association of black module genes with clinical traits. P-value <0.05 (−log10(p) >1.3, cut off was indicated by vertical red line) is considered statistically significant. GO: Gene Ontology; BP: biological pathway; CC: cellular component; MF: molecular function.