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[Preprint]. 2023 Jul 26:rs.3.rs-3147210. [Version 1] doi: 10.21203/rs.3.rs-3147210/v1

Figure 5. Homodimer blocking NICD compensatory mutation strategy.

Figure 5

(A) Crystal structure of dimerizing human N1ICD ankyrin domains from Arnett et al.. Positions of K1946 (blue) and E1950 (orange) are highlighted. Insets highlight charge interactions between adjacent NICDs and predicted interactions of NICD compensatory mutations. (B) Schematic representation of NICD compensatory mutations and predicted interactions. (C) Summary of amino acids mutated in mouse NICD molecules compared to human N1ICD.