Table 4.
Differentially methylated regions (false discovery rate [FDR] <0.05) in cord blood associated with exposure to O3 during pregnancy among 429 eligible mother-infant pairs in the Healthy Start study (2010–2014).
| Chromosome | Start position | End position | Raw p-value | Šidák-adjusted p-value | Annotated Gene(s) | Top CpG (lowest p-value) from region | Number of probes in region | Proportion of probes with positive association | Pregnancy period |
|---|---|---|---|---|---|---|---|---|---|
| 5 | 178986131 | 178986957 | 3.16E-11 | 7.57E-07 | RUFY1 | cg00080972 | 9 | 0 | Trimester 1 |
| 17 | 6899085 | 6899628 | 1.63E-10 | 5.94E-06 | ALOX12-AS1; ALOX12 | cg03407747 | 11 | 1 | Trimester 1 |
| 6 | 30038859 | 30039651 | 5.28E-10 | 1.32E-05 | RNF39 | cg03293507 | 35 | 0.03 | Trimester 1 |
| 6 | 29404667 | 29404784 | 1.33E-10 | 2.24E-05 | OR10C1 | cg02270518 | 4 | 1 | Trimester 1 |
| 16 | 2848409 | 2848881 | 1.32E-09 | 5.53E-05 | PRSS41 | cg27561907 | 4 | 1 | Trimester 1 |
| 11 | 368351 | 368763 | 4.61E-09 | 0.0002213 | B4GALNT4 | cg15971656 | 12 | 1 | Trimester 1 |
| 4 | 1523074 | 1523377 | 1.11E-08 | 0.0007214 | FAM53A | cg04300684 | 3 | 1 | Trimester 1 |
| 2 | 241075915 | 241076652 | 3.01E-08 | 0.0008075 | COPS9 | cg22062537 | 21 | 0.90 | Trimester 1 |
| 8 | 119086580 | 119086813 | 1.44E-08 | 0.001225 | EXT1 | cg20547777 | 3 | 0 | Trimester 1 |
| 19 | 39523158 | 39523677 | 5.84E-08 | 0.002224 | FBXO27 | cg02197293 | 5 | 0 | Trimester 1 |
| 11 | 1036677 | 1036989 | 6.30E-08 | 0.003984 | MUC6 | cg22685816 | 7 | 1 | Trimester 1 |
| 7 | 95025829 | 95026299 | 4.78E-07 | 0.01993 | PON3 | cg04080282 | 17 | 0 | Trimester 1 |
| 8 | 143859669 | 143860041 | 1.77E-11 | 9.42E-07 | LYNX1-SLURP2; LYNX1 | cg08090164 | 7 | 0 | Trimester 2 |
| 5 | 178986131 | 178986957 | 1.34E-09 | 3.21E-05 | RUFY1 | cg22764044 | 9 | 0 | Trimester 2 |
| 1 | 2885085 | 2885295 | 9.66E-09 | 0.0009094 | ACTRT2 | cg27537199 | 4 | 0 | Trimester 2 |
| 19 | 55417361 | 55417698 | 2.38E-08 | 0.001396 | NCR1 | cg12952132 | 6 | 1 | Trimester 2 |
| 1 | 1003126 | 1003580 | 6.82E-08 | 0.002966 | LOC105378948 | cg08709360 | 4 | 0 | Trimester 2 |
| 19 | 39523158 | 39523487 | 2.45E-07 | 0.01464 | FBXO27 | cg08404221 | 4 | 0 | Trimester 2 |
| 6 | 150346721 | 150347104 | 3.13E-07 | 0.01602 | RAET1L | cg20226154 | 10 | 0 | Trimester 2 |
| 11 | 34460107 | 34460608 | 4.22E-07 | 0.0165 | CAT | cg01847719 | 10 | 0 | Trimester 2 |
| 5 | 135416331 | 135416664 | 4.01E-07 | 0.02353 | VTRNA2–1 | cg18797653 | 9 | 0 | Trimester 2 |
| 13 | 113540400 | 113540682 | 4.38E-07 | 0.03025 | ATP11A | cg11520003 | 5 | 0 | Trimester 2 |
| 11 | 63775071 | 63775487 | 8.37E-07 | 0.03903 | MACROD1 | cg14085017 | 4 | 0 | Trimester 2 |
| 10 | 48416781 | 48417028 | 5.82E-07 | 0.04555 | GDF2 | cg06840491 | 7 | 1 | Trimester 2 |
| 3 | 182817190 | 182817677 | 3.99E-23 | 1.62E-18 | MCCC1 | cg03344955 | 11 | 0 | Trimester 3 |
| 5 | 102898223 | 102898784 | 6.32E-13 | 2.23E-08 | NUDT12 | cg02976617 | 6 | 0 | Trimester 3 |
| 8 | 689326 | 690110 | 1.81E-09 | 4.56E-05 | LOC401442; DLGAP2 | cg05022059 | 5 | 0 | Trimester 3 |
| 5 | 178986131 | 178986957 | 3.80E-09 | 9.10E-05 | RUFY1 | cg19626725 | 9 | 0 | Trimester 3 |
| 1 | 1003126 | 1003580 | 2.74E-08 | 0.001192 | LOC105378948 | cg08709360 | 4 | 0 | Trimester 3 |
| 5 | 177366867 | 177367064 | 1.92E-08 | 0.001921 | LOC100128340 | cg07372500 | 2 | 0 | Trimester 3 |
| 20 | 47013687 | 47013892 | 8.77E-08 | 0.008422 | LINC00494 | cg25181043 | 3 | 0 | Trimester 3 |
| 8 | 23162162 | 23162434 | 1.75E-07 | 0.01262 | LOXL2 | cg07396746 | 3 | 0 | Trimester 3 |
| 13 | 36871754 | 36872217 | 1.13E-06 | 0.04724 | CCDC169; CCDC169-SOHLH2 | cg11678027 | 11 | 0.09 | Trimester 3 |
| 5 | 178986131 | 178986957 | 3.24E-13 | 7.76E-09 | RUFY1 | cg00080972 | 9 | 0 | Full pregnancy |
| 17 | 6899085 | 6899628 | 1.03E-09 | 3.74E-05 | ALOX12-AS1; ALOX12 | cg03407747 | 11 | 1 | Full pregnancy |
| 19 | 39523158 | 39523677 | 1.79E-08 | 0.00068 | FBXO27 | cg02197293 | 5 | 0 | Full pregnancy |
| 6 | 29404667 | 29404784 | 7.62E-09 | 0.001287 | OR10C1 | cg02270518 | 4 | 1 | Full pregnancy |
| 2 | 241076131 | 241076652 | 6.92E-08 | 0.002623 | COPS9 | cg20221591 | 15 | 1 | Full pregnancy |
| 4 | 1523074 | 1523377 | 1.22E-07 | 0.007932 | FAM53A | cg04300684 | 3 | 1 | Full pregnancy |
| 1 | 2885085 | 2885295 | 2.11E-07 | 0.0197 | ACTRT2 | cg11737757 | 4 | 0 | Full pregnancy |
| 8 | 143859734 | 143860041 | 6.56E-07 | 0.04139 | LYNX1-SLURP2; LYNX1 | cg10555383 | 5 | 0 | Full pregnancy |