Table 3.
Summary of the selected studies on effective potential of L-carnitine in improving testicular radiation-induced dysfunctions
| Authors | Species and number | Radiation damages | Radiation dose | Treatment | Results |
|---|---|---|---|---|---|
| Topcu-Tarladacalisir et al. (2009) | 42 Wistar albino male rats |
Germ cell depletion and disorganization, spermatogenesis arrest, multinucleated giant cells formation, and germinal epithelium vacuolization | 10 dose of Gy γ-irradiation | LC (200 mg/kg) | LC enhanced the ratio of regeneration in seminiferous tubules and increased the recovery of spermatogenic cells after irradiation in rats |
| Kanter et al. (2010) | 18 Wistar albino male rats |
Germinal cell disorganization and desquamation, sperm count reduction in seminiferous tubule and an increment in TUNEL-positive cells in irradiated rats | 10 dose of Gy γ-irradiation | LC (200 mg/kg) | Pretreatment with LC, 24 hours before exposure to γ radiation, reduced radiation-induced germ cell apoptosis and significant testis histopathological changes |
| Ahmed et al. (2014) | 24 Swiss male mice |
Suppression of ABP expression and CYP450SCC mRNA, down-regulation of aromatase mRNA expression, up-regulation of FasL and cyclin D2 mRNA expression, up-regulation of TNF-α, IL1-β, and IFN-γ mRNA expressions | 0.1 doses of Gy/day (10 days) | LC (10 mg/kg) | LC decreased the apoptosis in testicular tissue and normalized the changes in the expression of testicular genes and sperm abnormalities in comparison with irradiated mice |
| Aktoz et al. (2017) | 30 Wistar albino male rats |
Spermatogenesis arrest, disorganization in the stratification of spermatogenic germ cells and vacuolization in the germinal epithelium | 20 doses of Gy γ-irradiation | LC (300 mg/kg) | LC has radioprotective effects against radiation-induced acute histopathological and biochemical testicular damage |
| Soliman and Aldhahrani (2020) | 28 Swiss male mice |
Induced testicular oxidative stress, changes in antioxidant activities, testicular dysfunction, and changes in apoptosis-associated genes (c-jun, c-fos, Bcl-xL, caspase-3, and BAX) | 0.1 doses of Gy/day (10 days) | L-carnitine LC (10 mg/kg) |
|