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. Author manuscript; available in PMC: 2023 Aug 4.
Published in final edited form as: Nat Immunol. 2022 Dec 21;24(2):267–279. doi: 10.1038/s41590-022-01379-9

Figure 3. CD8+ tTex cell ex vivo suppression is associated by tTex cell-intrinsic apoptosis.

Figure 3.

(A) Suppression assay of B16-F10 TIL from wild-type C57/BL6 or Il10−/− mice. (B) Suppression assay of B16-F10-derived tTex cells co-cultured with with activated C57/BL6 or Bcl2tg responding T cells. (C) Cleaved caspase-3 staining in CD8+ T cells from B16-F10 or MC38 tumors and draining lymph nodes (dLN). (D) Suppression assay of B16-F10 TIL from C57/BL6 or Bcl2tg mice. (E) Repeat experiments from Fig. 4D with live or Mytomycin C (MC)-killed tTex cells. Statistics are linear regression (A,B,D,E) and one-way ANOVA (C) with *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001.