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. 2018 Jul;24(7):10.18553/jmcp.2018.24.7.714. doi: 10.18553/jmcp.2018.24.7.714
Third Line LEN-DEX BOR-DEX CFZ-LEN-DEX ELO-LEN-DEX IX- LEN-DEX PAN-BOR-DEX DAR-LEN-DEX DAR-BOR-DEX
Total costs, $ 281,754 175,315 459,868 608,651 566,512 190,876 789,202 423,119
  Drug acquisition 237,670 121,751 401,201 541,632 516,793 131,500 707,051 344,684
  Supportive care 473 1,441 1,779 2,364 2,255 411 4,579 2,403
  Administration 7,365 8,113 13,394 3,095 22,394 21,412
  Progression 39,261 40,175 44,318 44,105 43,298 46,744 51,708 52,014
  Adverse event 4,351 4,583 4,457 7,156 4,I66 9,127 3,469 2,607
Total QALYs 2.04 2.16 2.74 2.71 2.60 3.23 4.38 4.38
  PFS 1.00 1.07 1.37 1.36 1.30 1.69 2.28 2.35
  Progression 1.03 1.09 1.37 1.36 1.30 1.54 2.10 2.03
Total life-years (OS) 3.25 3.44 4.37 4.32 4.14 4.93 6.97 6.71
  PFS 1.55 1.64 2.12 2.09 2.00 2.41 3.52 3.38
  Progression 1.70 1.79 2.25 2.23 2.14 2.52 3.44 3.33
ICER vs. LEN-DEX -853,800 252,293 484,168 508,021 Dominant 216,360 60,359