Third Line | LEN-DEX | BOR-DEX | CFZ-LEN-DEX | ELO-LEN-DEX | IX- LEN-DEX | PAN-BOR-DEX | DAR-LEN-DEX | DAR-BOR-DEX |
---|---|---|---|---|---|---|---|---|
Total costs, $ | 281,754 | 175,315 | 459,868 | 608,651 | 566,512 | 190,876 | 789,202 | 423,119 |
Drug acquisition | 237,670 | 121,751 | 401,201 | 541,632 | 516,793 | 131,500 | 707,051 | 344,684 |
Supportive care | 473 | 1,441 | 1,779 | 2,364 | 2,255 | 411 | 4,579 | 2,403 |
Administration | 7,365 | 8,113 | 13,394 | – | 3,095 | 22,394 | 21,412 | |
Progression | 39,261 | 40,175 | 44,318 | 44,105 | 43,298 | 46,744 | 51,708 | 52,014 |
Adverse event | 4,351 | 4,583 | 4,457 | 7,156 | 4,I66 | 9,127 | 3,469 | 2,607 |
Total QALYs | 2.04 | 2.16 | 2.74 | 2.71 | 2.60 | 3.23 | 4.38 | 4.38 |
PFS | 1.00 | 1.07 | 1.37 | 1.36 | 1.30 | 1.69 | 2.28 | 2.35 |
Progression | 1.03 | 1.09 | 1.37 | 1.36 | 1.30 | 1.54 | 2.10 | 2.03 |
Total life-years (OS) | 3.25 | 3.44 | 4.37 | 4.32 | 4.14 | 4.93 | 6.97 | 6.71 |
PFS | 1.55 | 1.64 | 2.12 | 2.09 | 2.00 | 2.41 | 3.52 | 3.38 |
Progression | 1.70 | 1.79 | 2.25 | 2.23 | 2.14 | 2.52 | 3.44 | 3.33 |
ICER vs. LEN-DEX | – | -853,800 | 252,293 | 484,168 | 508,021 | Dominant | 216,360 | 60,359 |