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Biodistribution studies.
| Organ | Marketed PI | NF | NFM |
|---|---|---|---|
| Lung (µg) | 1.45 ± 0.25 | 2.04 ± 0.27 a | 2.73 ± 0.19 a |
| Liver (µg) | 16.69 ± 0.20 | 18.34 ± 1.75 | 22.94 ± 0.81 a |
| Spleen (µg) | 2.97 ± 0.56 | 3.26 ± 1.01 | 3.94 ± 0.91 |
| Kidney (µg) | 1.79 ± 0.31 | 2.40 ± 0.87 | 2.29 ± 0.26 |
| Heart (µg) | 1.66 ± 0.65 | 1.52 ± 0.52 | 1.57 ± 0.45 |
Data was represented as Mean ± SD (n = 6).
= (p < 0.05); PI = powder for injection; NF , Nanoformulation without lyoprotectant; NFM , nanoformulation with mannitol.
