Table 2.
Clinical, diagnostic, and laboratory markers of tissue hypoperfusion.
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| 1. Decreased blood pressure: systolic < 90 mm Hg OR mean pressure < 60 mm Hg OR > 30 mm Hg drop from baseline |
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| 2. Tachycardia: heart rate > 100 beats/min |
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| 3. Weak or absent peripheral pulses |
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| 4. Cool, clammy, or mottled skin |
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| 5. Altered mental status |
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| 6. Decreased urine output < 30 mL/hr |
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| 7. Cardiac index < 2.2 |
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| 8. Pulmonary capillary wedge pressure > 15 mm Hg |
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| 9. Right atrial pressure ≥ 0.8 mm Hg |
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| 10. Pulmonary artery pulsatility index < 1.85 |
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| 11. Cardiac power output ≤ 0.6 watts |
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| 12. Mixed venous oxygen saturation (SvO2) < 60% |
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| 13. Elevated lactate > 2 mmol/L |
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| 14. Creatinine doubling |
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| 15. 50% drop in glomerular filtration rate |
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| 16. Deranged liver function |
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| 17. Elevated NT-pro brain natriuretic peptide |
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