The prediction performance of diagnostic biomarker panels derived from different sets of features are compared in each patient group, The number in the figure represents the averaged cross-validation AUC with 8 feature sets respectively in male (A), female (B), APOEɛ4+ (C), APOEɛ4- (D), male APOEɛ4+ (E), male APOEɛ4- (F), female APOEɛ4+ (G), male APOEɛ4- (H); All, all 127 metabolites in the data; All Clinic, all 127 metabolites in the data combines with age, BMI and/or education; DE: significant DE metabolites; DE Clinic: significant DE metabolites combined with age, BMI and/or education; Network: biomarkers derived from metabolic network; Network_DE: biomarkers derived from the combination of significant DE and metabolic network; Network_DE_Clinic: biomarkers derived from combination of significant DE metabolites, metabolic network and age, BMI, and/or education. Network_Clinic: biomarkers derived from metabolic network and age, BMI and/or education; (I) Two selected optimal biomarker panel association with clinical assessment and cognitive decline: The association of the two selected biomarker panel with and without Age, BMI and Education in each patient group (A: biomarker pane derived from metabolic network; B: biomarker pane derived from combination metabolic network plus age, BMI and/or education) with diagnosis (Dx) and clinical assessments (ADAS-Cog Total Score, memory function (ADNI_MEM) and executive function (ADNI_EF)).