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. 2023 Jul 11;14:1194610. doi: 10.3389/fimmu.2023.1194610

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Copyright © 2023 Zaitseva, Hoffmann, Löst, Anany, Zhang, Kucka, Wiegering, Otto and Wajant

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Triggering of Fn14 signaling by PDL192 type (2) and type (4) constructs. (A-C) The activity of PDL192-(2) and PDL192-(4) were analyzed as in Figure 2 with respect to enhancement of TNF-induced cell death in HeLa-RIPK3-FADD_KO cells (A), stimulation of p100 processing and TRAF1 indcution (B) and upregulation of IL8 production (C). IL8 data were averaged from seven independent experiments and were analyzed by one way ANOVA and Bonferroni post test. *p < 0.05, ***p < 0.001. (D, E) Purified PDL192-(2) and PDL192-(4) along with the parental antibody PDL192 were analyzed by SDS-PAGE and silverstaining (A) or gelfiltration analysis (E).