Figure 3. Landscape of somatic mutations and gene copy number alterations of endometrial cancers by molecular subtype integrating clinical sequencing and immunohistochemistry.

A. Oncoprints depicting the most recurrent somatic alterations in cancer-related genes in endometrial carcinomas by molecular subtype. Each column represents a tumor and the Oncoprint rows depict alterations for each gene. The bottom part of the graph shows the summary of histopathologic and clinical information for each case. The bar graph on the right of the panel shows the number and distribution of alterations for each gene across all subtypes. Mutation types and clinicopathologic features are color coded according to the legend. B. Tumor mutational burden in endometrial cancer by molecular subtype. C. Fraction of genome altered endometrial cancer by molecular subtype. P-value, Kruskal-Wallis rank sum test. CN-H, copy number-high; CN-L, copy number-low; MSI-H, microsatellite instability-high; N/A, not available; NOS, not otherwise specified.