Table 2.
The degree value sequence of some key targets of Coix seed decoction (CSD) against knee osteoarthritis (KOA).
| UniProt ID | Gene symbol | Protein names | Degree |
|---|---|---|---|
| P01375 | TNF | Tumor necrosis factor | 32 |
| P05231 | IL6 | Interleukin-6 | 32 |
| P14780 | MMP9 | Matrix metalloproteinase-9 | 31 |
| P01584 | IL1B | Interleukin-1 beta | 31 |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | 29 |
| P15692 | VEGFA | Vascular endothelial growth factor A | 28 |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | 28 |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 27 |
| P05112 | IL4 | Interleukin-4 | 27 |
| P04637 | TP53 | Cellular tumor antigen p53 | 26 |
| P01579 | IFNG | Interferon gamma | 26 |
| P03956 | MMP1 | Interstitial collagenase | 25 |
| P42574 | CASP3 | Caspase-3 | 25 |
| P01100 | FOS | Protein c-Fos | 25 |
| P00533 | EGFR | Epidermal growth factor receptor | 25 |
| P01106 | MYC | Myc proto-oncogene protein | 24 |
| P01583 | IL1A | Interleukin-1 alpha | 24 |
| P10451 | SPP1 | Osteopontin | 23 |
| Q14790 | CASP8 | Caspase-8 | 23 |
| P19438 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | 23 |
| P03372 | ESR1 | Estrogen receptor | 22 |
| P16581 | SELE | E-selectin | 22 |
| P24385 | CCND1 | G1/S-specific cyclin-D1 | 22 |
| P02778 | CXCL10 | C-X-C motif chemokine 10 | 21 |
| P04040 | CAT | Catalase | 20 |
| P19875 | CXCL2 | C-X-C motif chemokine 2 | 18 |
| P10914 | IRF1 | Interferon regulatory factor 1 | 18 |
| O14625 | CXCL11 | C-X-C motif chemokine 11 | 14 |
| P06401 | PGR | Progesterone receptor | 14 |
| P07204 | THBD | Thrombomodulin | 8 |
| P02461 | COL3A1 | Collagen alpha-1 (III) chain | 7 |
| P78380 | OLR1 | Oxidized low-density lipoprotein receptor 1 | 6 |
| P03973 | SLPI | Antileukoproteinase | 5 |
| Q14209 | E2F2 | Transcription factor E2F2 | 5 |