Table 3. Unadjusted and adjusted analyses of amygdalar activity vs. outcomes.

Covariates	Risk of Death HR [95% CI]	P-value
Unadjusted	1.35 [1.07–1.70]	0.009
Age and sex	1.34 [1.06–1.69]	0.013
Combined cardiac risk factors ¶	1.29 [1.03–1.62]	0.027
Combined cancer risk factors †	1.32 [1.03–1.69]	0.025
Combined Psychiatric risk factors ¥	1.35 [1.07–1.70]	0.009

AmygA activity was quantified as mean bilateral amygdalar activity corrected for background cerebral activity. The association between AmygA was corrected for accepted survival factors which were entered as cofactors in a stepwise manner.

^¶ The model was adjusted for age, sex, ASCVD risk score, prevalent diabetes, prevalent hypertension, prevalent dyslipidemia, and history of prior major CVD events at baseline.

^† The model was adjusted for age, sex, concurrent chemotherapy, surgery, radiation dose, hematocrit, and metastatic disease at baseline.

^¥The model was adjusted for age, sex, marital status, and history of depression or anxiety at baseline.

Numbers in parentheses are 95% CIs. Abbreviations: AmygA-amygdalar activity; ASCVD-Atherosclerotic cardiovascular disease; CI-confidence interval.