#	Query	Limiters/Expanders	Results
S1	(MH "weight gain+")	Search modes ‐ Boolean/Phrase	62,681
S2	(MH "weight loss+")	Search modes ‐ Boolean/Phrase	14,411
S3	TI obesity OR AB obesity	Search modes ‐ Boolean/Phrase	32,659
S4	TI obese OR AB obese	Search modes ‐ Boolean/Phrase	15,905
S5	TI adipos* OR AB adipos*	Search modes ‐ Boolean/Phrase	6,462
S6	TI weight gain OR AB weight gain	Search modes ‐ Boolean/Phrase	6,645
S7	TI weight loss OR AB weight loss	Search modes ‐ Boolean/Phrase	11,452
S8	TI overweight OR AB overweight	Search modes ‐ Boolean/Phrase	12,405
S9	TI over weight OR AB over weight	Search modes ‐ Boolean/Phrase	1,157
S10	TI overeat* OR AB overeat*	Search modes ‐ Boolean/Phrase	418
S11	TI over eat* OR AB over eat*	Search modes ‐ Boolean/Phrase	321
S12	TI weight change* OR AB weight change*	Search modes ‐ Boolean/Phrase	3,689
S13	(TI ((bmi or body mass index) N2 (gain or loss or change))) OR (AB ((bmi or body mass index) N2 (gain or loss or change)))	Search modes ‐ Boolean/Phrase	862
S14	TI body fat* OR AB body fat*	Search modes ‐ Boolean/Phrase	5,932
S15	TI body composition OR AB body composition	Search modes ‐ Boolean/Phrase	5,353
S16	TI body constitution OR AB body constitution	Search modes ‐ Boolean/Phrase	26
S17	(MH "Dietary Fats+")	Search modes ‐ Boolean/Phrase	17,455
S18	(MM "Diet, Fat‐Restricted")	Search modes ‐ Boolean/Phrase	901
S19	(TI (fat* N2 (total or intake or consum* or ate or eat or reduc* or restrict* or low* or diet*))) OR (AB (fat* N2 (total or intake or consum* or ate or eat or reduc* or restrict* or low* or diet*)))	Search modes ‐ Boolean/Phrase	11,074
S20	(S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16)	Search modes ‐ Boolean/Phrase	99,408
S21	(S17 OR S18 OR S19)	Search modes ‐ Boolean/Phrase	25,122
S22	(S20 AND S21)	Search modes ‐ Boolean/Phrase	6,404
S23	PT randomized controlled trial	Search modes ‐ Boolean/Phrase	45,326
S24	TX "controlled clinical trial"	Search modes ‐ Boolean/Phrase	7,628
S25	MM "Randomized Controlled Trials"	Search modes ‐ Boolean/Phrase	668
S26	MM "Random Assignment"	Search modes ‐ Boolean/Phrase	147
S27	MM "Double‐Blind Studies"	Search modes ‐ Boolean/Phrase	76
S28	MM "Single‐Blind Studies"	Search modes ‐ Boolean/Phrase	26
S29	S23 OR S24 OR S25 OR S26 OR S27 OR S28	Search modes ‐ Boolean/Phrase	52,650
S30	SU (animals not (human and animals))	Search modes ‐ Boolean/Phrase	53,619
S31	S29 NOT S30	Search modes ‐ Boolean/Phrase	52,575
S32	PT clinical trial	Search modes ‐ Boolean/Phrase	77,533
S33	MH "Clinical Trials+"	Search modes ‐ Boolean/Phrase	184,793
S34	TI (clin* N25 trial*) OR AB (clin* N25 trial*)	Search modes ‐ Boolean/Phrase	53,327
S35	TI ((singl* or doubl* or trebl* or tripl* or quad*) N (blind* or mask*)) OR AB ((singl* or doubl* or trebl* or tripl* or quad*) N (blind* or mask*))	Search modes ‐ Boolean/Phrase	300
S36	MM "Placebos"	Search modes ‐ Boolean/Phrase	828
S37	TI placebo* OR AB placebo*	Search modes ‐ Boolean/Phrase	27,852
S38	TI random* OR AB random*	Search modes ‐ Boolean/Phrase	144,733
S39	MM "study design"	Search modes ‐ Boolean/Phrase	5,275
S40	MM "comparative studies"	Search modes ‐ Boolean/Phrase	283
S41	MH "Evaluation Research+"	Search modes ‐ Boolean/Phrase	20,984
S42	MM "prospective studies"	Search modes ‐ Boolean/Phrase	800
S43	TI (control* or prospectiv* or volunteer*) OR AB (control* or prospectiv* or volunteer*)	Search modes ‐ Boolean/Phrase	357,450
S44	S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43	Search modes ‐ Boolean/Phrase	542,974
S45	S44 NOT S30	Search modes ‐ Boolean/Phrase	535,502
S46	S31 OR S45	Search modes ‐ Boolean/Phrase	541,731
S47	MH "prospective studies+"	Search modes ‐ Boolean/Phrase	254,176
S48	TX cohort* or quintile* or quartile* or quantile* or tertile*	Search modes ‐ Boolean/Phrase	152,914
S49	TX follow‐up* or followup*	Search modes ‐ Boolean/Phrase	249,854
S50	TX longitud*	Search modes ‐ Boolean/Phrase	103,954
S51	TX ((prospectiv* or observation*) N5 (research* or data* or stud*))	Search modes ‐ Boolean/Phrase	382,309
S52	S47 OR S48 OR S49 OR S50 OR S51	Search modes ‐ Boolean/Phrase	613,040
S53	S52 NOT S30	Search modes ‐ Boolean/Phrase	610,840
S54	S46 OR S53	Search modes ‐ Boolean/Phrase	963,714
S55	S22 AND S54	Search modes ‐ Boolean/Phrase	3,017
S56	S22 AND S54	Limiters ‐ Published Date: 20100101‐20151231; English Language Search modes ‐ Boolean/Phrase	1,236
S57	MH "Case Control Studies+"	Limiters ‐ Published Date: 20100101‐20151231; English Language Search modes ‐ Boolean/Phrase	23,820
S58	TX case N3 control*	Limiters ‐ Published Date: 20100101‐20151231; English Language Search modes ‐ Boolean/Phrase	35,592
S59	TX case N3 series	Limiters ‐ Published Date: 20100101‐20151231; English Language Search modes ‐ Boolean/Phrase	10,407
S60	MM "Case Studies"	Search modes ‐ Boolean/Phrase	623
S61	PT letter	Search modes ‐ Boolean/Phrase	198,888
S62	MH "Drug Therapy+"	Search modes ‐ Boolean/Phrase	109,541
S63	MH "Surgery, Operative+"	Search modes ‐ Boolean/Phrase	385,583
S64	MH "Biochemical Phenomena+"	Search modes ‐ Boolean/Phrase	29,949
S65	MH "Obesity+/DT/EC/RA/RT/SU"	Search modes ‐ Boolean/Phrase	5,470
S66	MH "Human Immunodeficiency Virus+"	Search modes ‐ Boolean/Phrase	5,947
S67	MH "HIV Infections+"	Search modes ‐ Boolean/Phrase	62,282
S68	TI cancer	Search modes ‐ Boolean/Phrase	137,532
S69	TI tumor OR tumour	Search modes ‐ Boolean/Phrase	21,392
S70	TI lung	Search modes ‐ Boolean/Phrase	24,925
S71	TI asthma	Search modes ‐ Boolean/Phrase	15,732
S72	S57 OR S58 OR S59 OR S60 OR S61 OR S62 OR S63 OR S64 OR S65 OR S66 OR S67 OR S68 OR S69 OR S70 OR S71	Search modes ‐ Boolean/Phrase	913,702
S73	S56 NOT S72	Search modes ‐ Boolean/Phrase	765