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. 2023 Jan 27;24(Suppl 1):S126–S138. doi: 10.1093/pm/pnad005

Table 2.

Deep phenotyping inclusion and exclusion criteria

Inclusion Criteria Exclusion Criteria
  • Right hand dominant

  • Normal visual acuity or correctable (with corrective lenses- glasses or contacts) to at least 20/40 for reading instructions in the MRI and visual sensitivity testing

  • No contraindications to MRI (eg, metal implants)

  • Willingness to refrain from taking any “as needed” medications, including pain medications such as NSAIDs (eg, Motrin, Advil, Aleve), acetaminophen (eg, Tylenol), and opioids, for 8 hours before undergoing neuroimaging and QST

  • Willingness to refrain from alcohol and nicotine on the day of QST and neuroimaging (alcohol and nicotine consumption is allowed after testing is completed)

  • Willingness to refrain from any unusual physical activity or exercise that would cause muscle and/or joint soreness for 48 hours prior to testing (routine exercise or activity that does not lead to soreness is acceptable)

  • Able to lie still on their back for 2 hours during MRI

  • Severe claustrophobia precluding MRI and evoked pain testing during scanning

  • Diagnosed peripheral neuropathy

  • Current, recent (within the last 6 months), or habitual use of artificial nails or nail enhancements. (Artificial nails can influence pressure pain sensitivity at the thumbnail)

  • BMI > 45 or unable to comfortably fit in the bore of the MRI magnet