Skip to main content
. Author manuscript; available in PMC: 2023 Aug 4.
Published in final edited form as: Structure. 2023 Apr 10;31(5):541–552.e4. doi: 10.1016/j.str.2023.03.010

Figure 4. The UBR5 tetramer structure.

Figure 4.

(A) Atomic model of the tetramer UBR5 in cartoon view. Two UBR5 chains (A and C) are colored as in Fig. 1c, and the two remaining chains in salmon. The red rectangle marks the tetramerization interface between two dimers that is mediated by the SBB2-SBB2 interaction. (B) Close-up view of the red rectangle region in panel a showing the EM density of SBB1/2 of protomers A and C in transparent surface superimposed with atomic model in cartoons. (C) Close-up view of the interface in the green box in panel b showing the SBB2 residues involved in tetramerization as predicted by AlphaFold-multimer.