Table 5.
Factors predicting treatment-free response outcome.
| Number | Successful TFR n = 9 |
Failed TFR n = 3 |
p value |
|---|---|---|---|
| Age at diagnosis in years, median [range]† | 50 [29–66] | 53 [45–59] | 0.60 |
| Total duration on TKI in months†, median [range] | 137 [87–192] | 96 [87–97] | 0.02 |
| Duration of DMR in months†, median [range] | 99 [83–113] | 70 [43–82] | 0.16 |
| Sokal score, n (%)∗ | 0.50 | ||
| Low | 5 (56) | 1 (33) | |
| Intermediate | 1 (11) | N/A | |
| High | 1 (11) | 2 (67) | |
| Indeterminate | 2 (22) | N/A | |
| Exposure to IFNα, n (%)∗ | 0.90 | ||
| No | 7 (78) | 3 (100) | |
| Yes | 2 (22) | 0 (0) | |
| Withdrawal symptoms, n (%)∗ | 0.50 | ||
| No | 3 (33) | 2 (67) | |
| Yes | 6 (67) | 1 (33) |
†Two-sample Wilcoxon rank-sum (Mann–Whitney) test; ∗Fisher's exact; IQR: interquartile range; MR: deep molecular remission; IFNα: interferon alpha; TKI: tyrosine kinase inhibitor.