Table 3.

Association of changes in systolic and diastolic BP over the prior 6 years with levels of circulating markers of inflammation in 46–49 years old women and men: the Hordaland Health Study.

	Women						Men						Interaction biomarker and sex
Variable	Univariable		Model 1		Model 2		Univariable		Model 1		Model 2		Univariable	Model 1	Model 2
	β	p	β	p	β	p	β	p	β	p	β	p	p	p	p
Δ systolic BP
hs-CRP	0.102	<0.01	0.067	<0.01	0.072	<0.01	0.016	0.54	−0.005	0.87	0.015	0.66	0.01	0.047	0.10
Neopterin	0.023	0.32	0.024	0.30	0.018	0.40	−0.012	0.64	−0.011	0.66	0.008	0.75	0.32	0.32	0.27
KTR	−0.006	0.81	−0.026	0.27	−0.037	0.11	−0.039	0.14	−0.044	0.093	−0.043	0.09	0.38	0.64	0.73
PAR index	0.012	0.60	0.015	0.53	0.011	0.63	0.024	0.36	0.026	0.33	0.047	0.05	0.76	0.76	0.37
Δ diastolic BP
hs-CRP	0.054	0.02	0.058	0.02	0.079	<0.01	−0.023	0.38	−0.029	0.28	0.006	0.80	0.03	0.03	0.09
Neopterin	0.065	<0.01	0.065	<0.01	0.074	<0.01	0.026	0.33	0.026	0.32	0.022	0.37	0.02	0.30	0.08
KTR	0.006	0.81	0.004	0.88	0.005	0.83	0.001	0.98	−0.0004	0.99	0.008	0.74	0.89	0.93	0.81
PAR index	0.014	0.54	0.014	0.54	0.027	0.22	0.039	0.14	0.039	0.14	0.072	<0.01	0.45	0.45	0.31

Model 1 is adjusted for body mass index. Model 2 is adjusted for body mass index, serum creatinine, physical activity, daily smoking, diabetes, and non-fasting serum triglycerides. In addition model 2 is adjusted systolic or diastolic BP at baseline in the models on change in systolic and diastolic BP, respectively.

β standardized B coefficient, BP blood pressure, hs-CRP high-sensitive C-reactive protein, PAr index ratio: 4-pyridoxic acid/(pyridoxal 5’-phosphate + pyridoxal), KTR kynurenin:tryptophan ratio.

Significant associations are printed in bold.