Table 3.

Global Brain Structure Relations With Intercept and Slope of the Psychopathology Factors Over Wave

	P		EXT		INT		ND		SOMAT		DETACH
Global Brain Structure	Std. β	95% CI	Std. β	95% CI	Std. β	95% CI	Std. β	95% CI	Std. β	95% CI	Std. β	95% CI
Total Cortical Volume
Intercept	−.098 ***	[−.120, −.076]	−.105 ***	[−.128, −.083]	−.003	[−.024, .019]	−.104 ***	[−.126, −.082]	−.022*	[−.043, −.000]	−.048 ***	[−.069, −.027]
Slope	.008	[−.000, .016]	.005	[−.004, .013]	.009	[−.001, .018]	.009*	[.001, .017]	.010	[−.001, .021]	−.001	[−.012, .010]
Total Subcortical Volume
Intercept	−.078 ***	[−.100, −.056]	−.080 ***	[−.103, −.058]	−.003	[−.025, .018]	−.089 ***	[−111, −.067]	−.010	[−.032, .011]	−.036 **	[−.057, −.016]
Slope	.003	[−.006, .011]	.003	[−.006, .011]	.001	[−.008, .010]	.003	[−.005, .012]	.004	[−.007, .015]	−.006	[−.017, .005]
Total Cortical Surface Area
Intercept	−.103 ***	[−.126, −.081]	−.113 ***	[−.136, −.091]	−.006	[−.028, .017]	−.106 ***	[−.129, −.084]	−.022*	[−.044, −.001]	−.043 ***	[−.064, −.022]
Slope	.006	[−.003, .014]	.006	[−.003, .014]	.003	[−.007, .012]	.006	[−.002, .014]	.006	[−.005, .017]	−.003	[−.014, .007]
Mean Cortical Thickness
Intercept	−.003	[−.023, .018]	.002	[−.018, .023]	.005	[−.015, .025]	−.010	[−.030, .011]	.002	[−.018, .022]	−.019	[−.038, .000]
Slope	.005	[−.003, .014]	−.002	[−.011, .006]	.014 **	[.004, .023]	.007	[−.001, .015]	.009	[−.002, .020]	.008	[−.003, .019]

Note: n=25,897 observations over three waves. Three-level linear growth models were run (Level 1 = within-subject repeated measures of psychopathology factor scores; Level 2 = within-site, between-subject differences; Level 3 = between-site differences). Intercept effects can be interpreted as the main effect of baseline brain structure on between-person differences in the psychopathology factor scores. Slope effects can be interpreted as interactions between baseline brain structure and wave. Site-level intercepts and slopes and covariates age, sex, scanner (dummy-coded) are not shown here (see Table S5, available online). Standardized estimates are shown. Estimates in bold survived FDR correction (q<0.05) for the 48 tests. CI = confidence interval; DETACH = detachment factor scores; EXT = externalizing factor scores; INT = internalizing factor scores; ND = neurodevelopmental factor scores; P = general psychopathology factor scores; SOMAT = somatization factor scores; Std. = standardized.

^*unadjusted p<.05

^**unadjusted p<.01

^***unadjusted p<.001