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. 2023 Jun 28;81(3):579–591. doi: 10.1007/s12020-023-03422-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Gene expression analysis in L6 performed 18 weeks after Orx in Non-Orx rats and Orx rats either untreated or treated with ostarine or testosterone. Relative expression of RANKL (A), OPG (B), OPG/RANKL ratio (C), OC (D), ALP (E), ERα (F), ERβ (G) and AR (H) were analyzed. a: differs from Non-Orx group; b: differs from Orx group, c: differs from Ostarine Therapy group, d: differs from Ostarine Proph. Group, e: differs from Test. Therapy group, f: differs from Test. Proph. group (p < 0.05, Tukey-test)