Fig. 6.

Following GlcN treatments there was an alteration of islet structure. Murine islets were isolated as outlined in Materials and methods. They were treated with 5 mM GlcN beginning 24 h after isolation, for 72 and 96 h. Islets were observed and photographed by three investigators, without knowledge of the experimental conditions. Black arrow indicates an insula preserving a normal morphology after GlcN treatment, yellow arrow indicates an insula with initial alterations of morphology, red arrow indicates an insula with an higher degree of alteration of morphology. n = 4