Table 3.

Main features of the selected studies

Author, year	Objective	Design	Sample, setting	Main result
PubMed database
Vriz et al. [2]	To describe the actual incidence and prevalence among patients with acute coronary syndrome, and the recurrence rate of TCM in the emergency department of a community hospital	Observational, prospectic	25 TCM patients	This study highlights an increase in the incidence rate of TCM in the general population, with a higher prevalence of TCM recurrence rate compared to data reported in previous studies
Cantey [16]	To describe the story of a woman who is diagnosed with TCM	Observational, case report	Woman, 71 y.o	Description of TCM syndrome and the evolution of the pathology in the woman considered in the case report
Ripa et al. [9]	Differential diagnosis recognition of TCM vs an acute myocardial infarction (MI)	Observational, case report	Woman, 78 y.o	Based on the limited increase in cardiac enzymes, the absence of coronary lesions, and the presence of typical echocardiographic changes, the Authors suspected a TCM syndrome
Strachinaru et al. [15]	Diagnosis of TCM in a woman with only an increase in cardiac troponin	Observational, case report	Woman, 83 y.o	TCM recognition in a woman with only increased cardiac troponin without symptoms corresponding to the syndrome
Padilla et al. [7]	Examination of the pathophysiology, signs and symptoms, diagnosis, and treatment of TCM	Observational, descriptive	22 subjects with TCM	List of signs and symptoms of TCM and description of some favorable patient outcomes
Massobrio et al. [14•]	To evaluate the mortality rate and all-cause survival in a series of female patients with TCM compared to STEMI (ST-Segment Elevation Myocardial Infarction) patients of the same age and sex during follow-up	Observational, prospectic	65 subjects with TCM	The TCM group had a lower mortality rate than the IMA group, which seems to suggest that TCM and IMA are two different clinical entities with different clinical outcomes
Scopus database
Sharkey et al. [13]	Comprehensive diagnostic investigations for the unexpected discovery of a catecholamine-producing pheochromocytoma	Observational, descriptive	2 male subjects of different age: 16 and 66 y.o	Observations show a common link between the occurrence of TCM and elevated catecholamine levels in both male and female patients with the presence of pheochromocytoma
Web of Science WOS database
Nyeche and Winokur [4]	Clinical manifestations of TCM	Observational, descriptive	Samples from different studies compared	Elements characterizing the diagnosis of TCM, especially cases of previous surgery
Griffin and Logue [3]	To describe the diagnostic criteria used for TCM	Observational, descriptive	22 women with TCM	Factors involved in the diagnosis of TCM in middle-aged women
Dahlviken et al. [5]	To describe the experiences of women with TCM cardiomyopathy from a short-term perspective	Observational, qualitative	14 women with TCM	Women suffering from TCM may be a target group for holistic and individual health care with a longer duration of follow-up
Google Scholar database
Wallström et al. [10]	Describe and interpret patients' narratives of the long-term stress experienced before the onset of TCM syndrome	Observational, qualitative	19 subjects with TCM	Long-term stressful circumstances can cause vulnerability to acute psychological or physical stressors and, subsequently, the onset of TCM syndrome
Sundelin et al. [8]	Describe the stress before and after the onset of TCM syndrome	Observational, mixed method	20 subjects with TCM	Patients with TCM syndrome reported long-term stress at times with an acute stress trigger before the onset of TCM syndrome. Stress decreased over time but remained high for a considerable number of patients
Brenner and Powers [11]	Describe TCM syndrome on social stressful events	Observational, case report	Woman, 77 y.o	Widowed woman with stressful event: emergency room course is described
Swenson et al. [1]	To review the physiology, diagnostics, treatment, and complications of TCM and to report a case study of a patient who developed TCM	Observational, review	Supporting information was obtained through the survey of academic articles on TCM over the past decade	APN is crucial in differentiating between TCM and acute myocardial infarction, heart failure, pulmonary edema, dynamic outflow obstruction, and cardiogenic shock
Derrick [6]	To describe the clinical manifestations of TCM	Observational, descriptive	Man, 65 y.o	Timely recognition of TCM results in fewer errors and consequences for the patient
Ghanim et al. [12]	To describe TCM as a result of insect bite	Observational, case report	Woman, 37 y.o	Therapeutic treatment after insect bite of a woman with TCM

PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analyses, APN advanced practice nurse