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. 2023 Aug 4;23(3):263. doi: 10.1007/s10142-023-01158-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pan-cancer overview of the ubiquitination-related genes. A, B CNV gain frequency and CNV loss frequency information among cancer types. The red color represents the gain frequency, whereas the blue color represents the loss frequency in the ubiquitination-related genes from pan-cancers. C SNV data among cancer types. The mutant frequencies of ubiquitination-associated genes in pan-cancers (red color to blue color represents low to high). D, E Differential expression traits of the ubiquitination-related genes in pan-cancers and their corresponding para-cancerous tissues (D log2FC values, E p values). F Prognostic contributions of the ubiquitination-related genes in pan-cancers. Genes (p > 0.05) were presented by white color, and the risky and protective genes were presented by blue and yellow colors, respectively. G Enrichment analysis for typical cancer-associated pathways between distinct URG-score crowds (NES, normalized enrichment score)