Table 3.
Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | |
Primary cohort | ||||
Sex: male vs. female | 0.66 (0.48–0.90) | 0.010* | 0.79 (0.57–1.09) | 0.156 |
Age: > 60 vs. ≤ 60 | 1.27 (0.99–1.63) | 0.061 | ||
Tumor location | ||||
Lower vs. upper + middle | 0.90 (0.78–1.04) | 0.158 | ||
Grade | ||||
Poorly vs. Well + moderately | 1.79 (1.39–2.30) | < 0.001* | 1.68 (0.95–2.98) | 0.074 |
T stage | ||||
T2–4a vs. T1 | 3.01 (2.12–4.27) | < 0.001* | 2.27 (1.58–3.28) | < 0.001* |
N stage | ||||
N1–3 vs. N0 | 2.80 (2.17–3.61) | < 0.001* | 2.02 (1.54–2.65) | < 0.001* |
TNM stage | ||||
II–IVa vs. I | 3.86 (2.57–5.80) | < 0.001* | 3.57 (2.37–5.37) | < 0.001* |
Fibrinogen: ≥ 3.5 vs. < 3.5 | 1.46 (1.14–1.88) | 0.003* | 1.35 (1.05–1.74) | 0.019* |
NLR: ≥ 1.95 vs. < 1.95 | 1.47 (1.13–1.89) | 0.003* | 1.33 (1.03–1.73) | 0.031* |
PLR: ≥ 130 vs. < 130 | 1.32 (1.03–1.69) | 0.031* | 1.19 (0.93–1.53) | 0.164 |
MLR: ≥ 0.25 vs. < 0.25 | 1.34 (1.04–1.73) | 0.025* | 1.17 (0.90–1.51) | 0.242 |
F-NLR | ||||
1–2 vs. 0 | 1.62 (1.20–2.18) | 0.002* | 1.39 (1.03–1.88) | 0.030* |
Validation cohort | ||||
Sex: male vs. female | 0.66 (0.37–1.15) | 0.139 | ||
Age: > 60 vs. ≤ 60 | 0.93 (0.60–1.44) | 0.742 | ||
Tumor location | ||||
Lower vs. upper + middle | 1.02 (0.80–1.30) | 0.877 | ||
Grade | ||||
Poorly vs. well + moderately | 2.33 (1.48–3.68) | < 0.001* | 1.87 (1.18–2.97) | 0.008* |
T stage | ||||
T2–4a vs. T1 | 2.79 (1.39–5.58) | < 0.001* | 2.16 (1.07–4.37) | 0.032* |
N stage | ||||
N1–3 vs. N0 | 2.45 (1.57–3.83) | < 0.001* | 1.84 (1.16–2.91) | 0.010* |
TNM stage | ||||
II–IVa vs. I | 3.24 (1.41–7.44) | 0.006* | 2.62 (1.13–6.10) | 0.026* |
Fibrinogen: ≥ 3.5 vs. < 3.5 | 1.80 (1.15–2.81) | 0.010* | 1.60 (1.02–2.51) | 0.039* |
NLR: ≥ 1.95 vs. < 1.95 | 1.96 (1.26–3.04) | 0.003* | 1.81 (1.14–2.87) | 0.012* |
PLR: ≥ 130 vs. < 130 | 1.64 (1.05–2.57) | 0.031* | 1.55 (0.98–2.44) | 0.059 |
MLR: ≥ 0.25 vs. < 0.25 | 1.72 (1.08–2.74) | 0.022* | 1.50 (0.94–2.42) | 0.092 |
F-NLR | ||||
1–2 vs. 0 | 1.96 (1.10–3.48) | 0.023* | 1.84 (1.03–3.27) | 0.039* |
F-NLR: Fibrinogen-neutrophil lymphocyte ratio; NLR: neutrophil lymphocyte ratio; PLR: platelet lymphocyte ratio; MLR: monocyte to lymphocyte ratio