Table 2.

Statistically significant results of the gene-environment interaction analyses for diabetes and single genetic variants for colorectal cancer risk.

Variant	Chr	BP position	Closest gene	Annotation	Reference allele	Alternate allele	Alternate allele frequency	Method	P (D|G)a	P (E|G)b	P (GxE)c	P-valued (Covariate set 1)e	P-valued (Covariate set 2)f
Primary GxE testing
rs3802177	8	118185025	SLC30A8	3’ UTR	G	A	0.31	3-d.f. joint test	4.05 × 10−01	4.90 × 10−10	7.49 × 10−04	5.46 × 10−11	1.01 × 10−10
Secondary GxE testing
rs9526201	13	47191972	LRCH1	intron	G	A	0.82	2-d.f. joint test	1.87 × 10−04	NA	1.33 × 10−06	7.84 × 10−09	8.82 × 10−09

Chr chromosome, BP Position base pair position based on NCBI Build 37, d.f. degrees of freedom, UTR Untranslated region, NA not applicable.

^aP-value corresponds to the association between genetic variants and colorectal cancer.

^bP-value corresponds to the association between genetic variants and diabetes.

^cP-value corresponds to the interaction between genetic variants and diabetes on risk of colorectal cancer.

^dP-values correspond to each method used to test for interactions between genetic variants and diabetes.

^eCovariate set 1: age at baseline, sex, study, genotyping platform, and the first three principal components (Colorectal cancer cases = 31,318, Controls = 41,499).

^fCovariate set 2: covariate set 1 plus additional adjustment for body mass index.