Table 3.
Stratified analysis for gene-diabetes interactions for colorectal cancer that were statistically significant.
| Primary GxE testing: rs3802177, chromosome 8, SLC30A8 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | per G allele stratified by diabetes | ||||||||
| #cases /#controls | OR (95% CI) | p-value | #cases /#controls | OR (95% CI) | p-value | #cases /#controls | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Diabetes = No | 2605/3640 | 1.00 (Ref.) | – | 11848/16321 | 1.00 (0.95–1.06) | 9.3 × 10−01 | 13307/18333 | 1.01 (0.95–1.07) | 8.5 × 10−01 | 1.00 (0.98–1.03) | 8.2 × 10−01 |
| Diabetes = Yes | 300/227 | 1.62 (1.34–1.96) | 7.5 × 10−07 | 1496/1285 | 1.42 (1.29–1.56) | 1.2 × 10−12 | 1762/1694 | 1.23 (1.12–1.34) | 7.5 × 10−06 | 0.87 (0.80–0.94) | 5.4 × 10−04 |
| OR for diabetes stratified by genotype | – | 1.62 (1.34–1.96) | 7.5 × 10−07 | – | 1.41 (1.3–1.54) | 6.2 × 10−16 | – | 1.22 (1.13–1.31) | 2.4 × 10−07 | ||
| Secondary GxE testing: rs9526201, chromosome 13, LRCH1 | |||||||||||
| GG | GA | AA | per A allele stratified by diabetes | ||||||||
| #cases /#controls | OR (95% CI) | p-value | #cases /#controls | OR (95% CI) | p-value | #cases /#controls | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Diabetes = No | 859/1342 | 1.00 (Ref.) | – | 7958/11639 | 1.06 (0.96–1.17) | 2.2 × 10−01 | 18943/25313 | 1.15 (1.05–1.27) | 2.9 × 10−03 | 1.08 (1.05–1.11) | 4.7 × 10−7 |
| Diabetes = Yes | 133/92 | 2.11 (1.56–2.83) | 8.9 × 10−07 | 1068/902 | 1.62 (1.42–1.84) | 7.5 × 10−13 | 2358/2212 | 1.3 (1.16–1.46) | 1.8 × 10−09 | 0.85 (0.77–0.93) | 5.9 × 10−4 |
| OR for diabetes stratified by genotype | – | 2.11 (1.56–2.83) | 8.9 × 10−07 | – | 1.52 (1.38–1.68) | 1.1 × 10−16 | – | 1.13 (1.06–1.21) | 3.8 × 10−09 | ||
Number of case/control counts were calculated by imputed genotype probabilities. Analyses were adjusted for age at baseline, sex, study, genotyping platform, and the first three principal components.
Odds ratios (OR) and 95% confidence interval (CI) are shown for association of diabetes with colorectal cancer risk stratified by genotype (rs3802177 and rs9526201) and for association of genotype with colorectal cancer risk stratified by diabetes.