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. 2023 Jun 28;129(3):426–443. doi: 10.1038/s41416-023-02313-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Violin plot showing the global FOSL2 expression level from scRNA-seq in the low FOSL2 ductal cell group and high FOSL2 group. b Volcano plot exhibited differentially expressed RNA in the high FOSL2 group vs. the low FOSL2 group. c GO term analysis showed the up-regulated signalling pathway in the high FOSL2 group compared with the low FOSL2 group. d GO term analysis showed the down-regulated signalling pathway in the high FOSL2 group compared with the low FOSL2 group. e Immunoblot showing the abundance of FOSL2 in tumour xenograft of indicated groups. f PanO2 cells transfected with Vector or oe-FOSL2 were injected subcutaneously into C57BL/6 mice. Tumour volume was monitored and measured. Data are shown as mean ± SD. ***P < 0.001. g Representative images show tumour volume in the indicated groups. h Graphical quantification of difference in tumour weight on day 21 in Vector or oe-FOSL2 cohorts. Data are shown as mean ± SEM. ***P < 0.001. i Representative flow staining of CD4⁺ and CD8⁺ T cells gated on CD45⁺CD3⁺ cells in tumour xenograft of indicated groups. j Representative flow staining of CD25⁺Foxp3⁺ Treg cells gated on CD45⁺CD3⁺ CD4⁺ cells in tumour xenograft of indicated groups. k The frequency of CD8⁺, CD4⁺, and Treg cells in tumour xenograft of the indicated groups. **P < 0.01; n.s. not significant.