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. 2023 Jun 24;129(3):521–530. doi: 10.1038/s41416-023-02325-8

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Fig. 4 — a Among interferons, mRNA interferon-β expression in HGECs with down-regulated INSR is greatly elevated by approximately 1200-fold more than the control. b Protein secretion of interferon-β in HGEC supernatant with down-regulated INSR is remarkably elevated than in the control. c In HGECs with axitinib, INSR protein expression of HGECs is decreased in a concentration-dependent manner on Western blot analysis. d In HGECs with axitinib, mRNA interferon-β expression of HGECs is increased concentration-dependently. e When a Caki-1 cell line is co-cultured with HGECs with down-regulated INSR, mRNA PD-L1 expression of the Caki-1 cell line is increased by more than ten times compared to the control along with increased protein PD-L1 expression. f When recombinant interferon-β is directly administered to a Caki-1 cell line, mRNA expression of PD-L1 in the Caki-1 cell line is increased concentration-dependently.