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. 2023 Aug 4;13:12687. doi: 10.1038/s41598-023-39555-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Altered cecal contraction patterns in Nlgn3^R451C mice. (A) The percentage of CeMCs showing the contraction pattern is significantly lower in Nlgn3 mice. (B) The cecal-colonic contraction interval is significantly shorter in Nlgn3 mice. (C,D) Characteristics of individual contractions within CeMCs. (C) Alterations to velocity, duration, and start position of the forward contraction (FC) in Nlgn3 mice. (D) For reverse contractions (RC), the velocity is comparable, however their duration is shorter in Nlgn3 mice compared to WT. Cecal motility parameters were analysed using Student’s unpaired t-test. All measures of cecal motility were assessed using the Benjamini–Hochberg procedure to account for false discovery rate. Individual data and mean ± SD were plotted for n = 11 mice in each group. ns = p > 0.05, *p < 0.05, **p < 0.01. WT = wildtype; Nlgn3 = Nlgn3^R451C.