Abstract
A controlled trial of oral acyclovir in herpetic dendritic corneal ulcers was carried out on 31 patients. All patients received minimal wiping debridement of the ulcer, following which they were randomly allocated to receive either oral acyclovir or placebo for 7 days. At the end of treatment 67% of dendritic ulcers in patients receiving acyclovir had healed compared with 43% in placebo recipients. The proportion of ulcers healed in the 2 groups at 7 days showed no significant difference (p = 0.18), but the rate of healing was significantly faster in acyclovir group (p = 0.03).
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Selected References
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- Colin J., Tournoux A., Chastel C., Renard G. Kératite herpétique superficielle. Traitement comparatif en double insu par acycloriv et idoxuridine. Nouv Presse Med. 1981 Oct 10;10(36):2969-70, 2975. [PubMed] [Google Scholar]
- Collum L. M., Benedict-Smith A., Hillary I. B. Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration. Br J Ophthalmol. 1980 Oct;64(10):766–769. doi: 10.1136/bjo.64.10.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coster D. J., Wilhelmus K. R., Michaud R., Jones B. R. A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis. Br J Ophthalmol. 1980 Oct;64(10):763–765. doi: 10.1136/bjo.64.10.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones B. R., Coster D. J., Falcon M. G., Cantell K. Topical therapy of ulcerative herpetic keratitis with human interferon. Lancet. 1976 Jul 17;2(7977):128–128. doi: 10.1016/s0140-6736(76)92850-6. [DOI] [PubMed] [Google Scholar]
- Jones B. R., Coster D. J., Fison P. N., Thompson G. M., Cobo L. M., Falcon M. G. Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers. Lancet. 1979 Feb 3;1(8110):243–244. doi: 10.1016/s0140-6736(79)90769-4. [DOI] [PubMed] [Google Scholar]
- Jones B. R., Coster D. J., Fison P. N., Thompson G. M., Cobo L. M., Falcon M. G. Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers. Lancet. 1979 Feb 3;1(8110):243–244. doi: 10.1016/s0140-6736(79)90769-4. [DOI] [PubMed] [Google Scholar]
- Klauber A., Ottovay E. Acyclovir and idoxiuridine treatment of herpes simplex keratitis--a double blind clinical study. Acta Ophthalmol (Copenh) 1982 Oct;60(5):838–844. doi: 10.1111/j.1755-3768.1982.tb06748.x. [DOI] [PubMed] [Google Scholar]
- Laibson P. R., Pavan-Langston D., Yeakley W. R., Lass J. Acyclovir and vidarabine for the treatment of herpes simplex keratitis. Am J Med. 1982 Jul 20;73(1A):281–285. doi: 10.1016/0002-9343(82)90106-1. [DOI] [PubMed] [Google Scholar]
- McCulley J. P., Binder P. S., Kaufman H. E., O'Day D. M., Poirier R. H. A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis. Ophthalmology. 1982 Oct;89(10):1195–1200. doi: 10.1016/s0161-6420(82)34668-0. [DOI] [PubMed] [Google Scholar]
- McGill J., Tormey P., Walker C. B. Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers. Br J Ophthalmol. 1981 Sep;65(9):610–613. doi: 10.1136/bjo.65.9.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Young B. J., Patterson A., Ravenscroft T. A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration. Br J Ophthalmol. 1982 Jun;66(6):361–363. doi: 10.1136/bjo.66.6.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van der Meer J. W., Versteeg J. Acyclovir in severe herpes virus infections. Am J Med. 1982 Jul 20;73(1A):271–274. doi: 10.1016/0002-9343(82)90104-8. [DOI] [PubMed] [Google Scholar]