Table 1.
Clinical course of patients treated with avacopan
| Patient | Cr at presentation (Day 0) | Cr at HD initiation (Day) | Day of steroid initiation | Day of avacopan initiation | Prednisone (mg) at avacopan initiation | Remission (BVAS = 0) | Resolution of hematuria (Day) | Serologic remission (Day) | Day of last HD | Cr at last follow-up (Day) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2.3 | 4.9 (10) | 4 | 15 | 40 | Yes | 155 | Y (113) | 125 | 2.2 (265) |
| 2 | 5.54 | 5.6 (2) | 2 | 49 | 15 | Yes | 150 | Y (68) | 192 | 2.0 (224) |
| 3 | 4.8 | 6.9 (4) | 1 | 9 | 60 | Yes | 124 | Y (60) | 14 | 1.4 (269) |
BVAS, Birmingham Vasculitis Activity Score. Cr, serum creatinine. HD, hemodialysis.
Resolution of hematuria was defined as heme negativity on dipstick and ≤ 2 RBCs/hpf. Serologic remission was defined as a negative test for antibodies to myeloperoxidase or proteinase-3.