Table 1.
Baseline demographic data presented by ARRS category
| ARRS Category | Total | Low | Medium | High | P |
|---|---|---|---|---|---|
| N | 288 | 144 | 132 | 12 | - |
| Sex – Female n (%) | 139 (48.3) | 68 (47.2) | 65 (49.2) | 6 (50.0) | 0.94 |
| Age (yrs): mean (SD) | 66.9 (12.3) | 66.1 (12.1) | 68.3 (11.9) | 61.0 (16.0) | 0.07 |
| Creatinine (μmol/l): median (IQR) | 216 [142, 342] | 153 [105, 210] | 318 [217, 465] | 566 [523, 772] | <0.001 |
| eGFR (CKD-EPI, ml/min per 1.73 m2): median (IQR) |
22 [13, 37] | 34 [22, 54] | 13 [9, 23] | 7 [4, 8] | <0.001 |
| Urinary PCR (mg/mmol): median (IQR) | 136 [69, 269] | 91 [45, 167] | 190 [106, 366] | 494 [211, 697] | <0.001 |
| PR3 (%) | 106 (36.8) | 54 (37.5) | 43 (32.6) | 9 (75.0) | <0.01 |
| MPO (%) | 182 (63.2) | 90 (62.5) | 89 (67.4) | 3 (25.0) | - |
| Corticosteroid (%) | 286 (99.3) | 143 (99.3) | 131 (99.2) | 12 (100.0) | 0.95 |
| Cyclophosphamide (%) | 215 (74.7) | 104 (72.2) | 101 (76.5) | 10 (83.3) | 0.56 |
| Rituximab (%) | 45 (15.6) | 17 (11.8) | 25 (18.9) | 3 (25.0) | 0.17 |
| Plasma exchange (%) | 56 (19.4) | 9 (6.2) | 38 (28.8) | 9 (75.0) | <0.01 |
| KRT at baseline (%) | 34 (11.8) | 0 (0) | 25 (18.9) | 9 (75) | <0.001 |
| Pulmonary hemorrhage (%) | 21 (7.3) | 9 (6.2) | 8 (6.1) | 4 (33.3) | <0.01 |
| SIMD 1st quintile n (%) | 58 | 32 (22.2) | 25 (18.9) | 1 (8.3) | 0.254 |
| SIMD 2nd quintile n (%) | 57 | 25 (17.4) | 26 (19.7) | 6 (50) | - |
| SIMD 3rd quintile n (%) | 51 | 30 (20.8) | 20 (15.2) | 1 (8.3) | - |
| SIMD 4th quintile n (%) | 60 | 29 (20.1) | 29 (22.0) | 2 (16.7) | - |
| SIMD 5th quintile n (%) | 62 | 28 (19.4) | 32 (24.2) | 2 (16.7) | - |
ARRS, ANCA Renal Risk Score; eGFR, estimated glomerular filtration rate; KRT, kidney replacement therapy; MPO, positive autoantibody to myeloperoxidase; PCR, protein-to-creatinine ratio; PR3, positive autoantibody to proteinase 3; SIMD, Scottish Index of Multiple Deprivation, quintile 1 = most deprived.